相互作用
Atazanavir + Desogestrel-ethinyl estradiol
重症度: 重大
Atazanavir and Desogestrel-ethinyl estradiol: major interaction.
最終更新日
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概要
Atazanavir alters ethinyl estradiol exposure, and when boosted with ritonavir can reduce it, while progestin exposure may increase. This may lead to reduced contraceptive reliability, breakthrough bleeding, or progestin-related adverse effects.
この相互作用をわかりやすく説明すると
Atazanavir and Desogestrel-ethinyl estradiol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Desogestrel-ethinyl estradiol belongs to Endocrine.
なぜ起こるのか
Atazanavir inhibits CYP3A4 and UGT1A1, while ritonavir boosting induces glucuronidation, altering ethinyl estradiol and progestin levels.
対処法
Use a contraceptive containing at least 30 mcg ethinyl estradiol with unboosted atazanavir, or choose an alternative or additional non-hormonal method. Avoid products with less than 30 mcg ethinyl estradiol with boosted atazanavir.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AtazanavirとDesogestrel-ethinyl estradiolの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Desogestrel-ethinyl estradiolのその他の相互作用
Atazanavirのその他の相互作用
よくある質問
Can I take Atazanavir with Desogestrel-ethinyl estradiol?
MediHelp rates the interaction as major. Atazanavir and Desogestrel-ethinyl estradiol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir alters ethinyl estradiol exposure, and when boosted with ritonavir can reduce it, while progestin exposure may increase. This may lead to reduced contraceptive reliability, breakthrough bleeding, or progestin-related adverse effects.
How serious is the interaction between Atazanavir and Desogestrel-ethinyl estradiol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a contraceptive containing at least 30 mcg ethinyl estradiol with unboosted atazanavir, or choose an alternative or additional non-hormonal method. Avoid products with less than 30 mcg ethinyl estradiol with boosted atazanavir.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
