相互作用
Apixaban + Ketorolac
重症度: 併用禁忌
Apixaban and Ketorolac: contraindicated interaction.
最終更新日
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概要
Ketorolac inhibits platelet function and damages the gastric mucosa, which adds to the bleeding risk of apixaban. Serious gastrointestinal and other hemorrhages may result. Ketorolac labeling contraindicates its use with anticoagulants at therapeutic doses.
この相互作用をわかりやすく説明すると
Apixaban and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apixaban belongs to Cardiovascular; Ketorolac belongs to Musculoskeletal.
なぜ起こるのか
Additive hemostatic impairment: NSAID antiplatelet effect and mucosal injury combined with factor Xa inhibition.
対処法
Avoid the combination and use a non-NSAID analgesic such as paracetamol. If an NSAID is absolutely needed, choose a different agent at the lowest dose with gastroprotection and bleeding monitoring.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ApixabanとKetorolacの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ketorolacのその他の相互作用
Apixabanのその他の相互作用
よくある質問
Can I take Apixaban with Ketorolac?
MediHelp rates the interaction as contraindicated. Apixaban and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketorolac inhibits platelet function and damages the gastric mucosa, which adds to the bleeding risk of apixaban. Serious gastrointestinal and other hemorrhages may result. Ketorolac labeling contraindicates its use with anticoagulants at therapeutic doses.
How serious is the interaction between Apixaban and Ketorolac?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-NSAID analgesic such as paracetamol. If an NSAID is absolutely needed, choose a different agent at the lowest dose with gastroprotection and bleeding monitoring.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
