相互作用
Apixaban + Edoxaban
重症度: 併用禁忌
Apixaban and Edoxaban: contraindicated interaction.
最終更新日
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概要
Both are direct factor Xa inhibitors, so using them together duplicates anticoagulation and markedly increases bleeding risk with no added benefit. Overlap is acceptable only briefly when switching between agents.
この相互作用をわかりやすく説明すると
Apixaban and Edoxaban are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apixaban belongs to Cardiovascular; Edoxaban belongs to Cardiovascular.
なぜ起こるのか
Duplicate pharmacodynamic effect through factor Xa inhibition.
対処法
Do not co-prescribe. When switching, stop one agent and start the other at the time the next dose of the first would be due.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ApixabanとEdoxabanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Apixabanのその他の相互作用
Edoxabanのその他の相互作用
よくある質問
Can I take Apixaban with Edoxaban?
MediHelp rates the interaction as contraindicated. Apixaban and Edoxaban are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are direct factor Xa inhibitors, so using them together duplicates anticoagulation and markedly increases bleeding risk with no added benefit. Overlap is acceptable only briefly when switching between agents.
How serious is the interaction between Apixaban and Edoxaban?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-prescribe. When switching, stop one agent and start the other at the time the next dose of the first would be due.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Ketorolac. The full list is on the Apixaban page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
