相互作用
Armodafinil + Pretomanid
重症度: 重大
Armodafinil and Pretomanid: major interaction.
最終更新日
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概要
Armodafinil may lower pretomanid concentrations by inducing CYP3A4. Reduced exposure could compromise the efficacy of tuberculosis regimens and promote resistance. Labeling advises avoiding strong and moderate CYP3A4 inducers.
この相互作用をわかりやすく説明すると
Armodafinil and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Armodafinil belongs to Central Nervous System; Pretomanid belongs to Anti Bacterial.
なぜ起こるのか
CYP3A4 induction by armodafinil increases the metabolism of pretomanid, a CYP3A4 substrate.
対処法
Avoid the combination and use a non-inducing alternative to armodafinil. If unavoidable, monitor the clinical and microbiologic response.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ArmodafinilとPretomanidの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Armodafinilのその他の相互作用
Pretomanidのその他の相互作用
よくある質問
Can I take Armodafinil with Pretomanid?
MediHelp rates the interaction as major. Armodafinil and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Armodafinil may lower pretomanid concentrations by inducing CYP3A4. Reduced exposure could compromise the efficacy of tuberculosis regimens and promote resistance. Labeling advises avoiding strong and moderate CYP3A4 inducers.
How serious is the interaction between Armodafinil and Pretomanid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing alternative to armodafinil. If unavoidable, monitor the clinical and microbiologic response.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Cyclosporine, Elacestrant. The full list is on the Armodafinil page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
