相互作用
Amiodarone + Pretomanid
重症度: 重大
Amiodarone and Pretomanid: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
The pretomanid regimen is associated with hepatotoxicity and amiodarone can also injure the liver. Using them together may increase the risk of liver injury.
この相互作用をわかりやすく説明すると
Amiodarone and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Pretomanid belongs to Anti Bacterial.
なぜ起こるのか
Additive hepatotoxicity.
対処法
Avoid if possible; otherwise monitor liver enzymes closely and stop therapy if significant hepatic injury develops.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmiodaroneとPretomanidの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Amiodaroneのその他の相互作用
Pretomanidのその他の相互作用
よくある質問
Can I take Amiodarone with Pretomanid?
MediHelp rates the interaction as major. Amiodarone and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The pretomanid regimen is associated with hepatotoxicity and amiodarone can also injure the liver. Using them together may increase the risk of liver injury.
How serious is the interaction between Amiodarone and Pretomanid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor liver enzymes closely and stop therapy if significant hepatic injury develops.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
