相互作用
Azathioprine + Pretomanid
重症度: 重大
Azathioprine and Pretomanid: major interaction.
最終更新日
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概要
Pretomanid-containing regimens are associated with liver toxicity, and azathioprine can also cause hepatic injury. Using them together raises the risk of hepatotoxicity.
この相互作用をわかりやすく説明すると
Azathioprine and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azathioprine belongs to Gastrointestinal Tract; Pretomanid belongs to Anti Bacterial.
なぜ起こるのか
Additive hepatotoxicity from two drugs with independent liver injury potential.
対処法
Avoid azathioprine during pretomanid regimens when possible. If both are needed, monitor liver enzymes and bilirubin regularly and interrupt therapy if significant injury develops.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AzathioprineとPretomanidの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Azathioprineのその他の相互作用
Pretomanidのその他の相互作用
よくある質問
Can I take Azathioprine with Pretomanid?
MediHelp rates the interaction as major. Azathioprine and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pretomanid-containing regimens are associated with liver toxicity, and azathioprine can also cause hepatic injury. Using them together raises the risk of hepatotoxicity.
How serious is the interaction between Azathioprine and Pretomanid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid azathioprine during pretomanid regimens when possible. If both are needed, monitor liver enzymes and bilirubin regularly and interrupt therapy if significant injury develops.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
