相互作用
Arsenic trioxide + Quinidine
重症度: 併用禁忌
Arsenic trioxide and Quinidine: contraindicated interaction.
最終更新日
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概要
Both drugs prolong the QT interval, and arsenic trioxide is also linked to torsades de pointes and complete AV block. Combined use raises the risk of life-threatening ventricular arrhythmia.
この相互作用をわかりやすく説明すると
Arsenic trioxide and Quinidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Arsenic trioxide belongs to Oncology; Quinidine belongs to Anti Parasitic.
なぜ起こるのか
Additive blockade of cardiac repolarizing potassium currents causing QT prolongation.
対処法
Avoid the combination and choose a non-QT-prolonging antiarrhythmic. If unavoidable, correct potassium and magnesium and monitor ECG closely.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Arsenic trioxideとQuinidineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Quinidineのその他の相互作用
Arsenic trioxideのその他の相互作用
よくある質問
Can I take Arsenic trioxide with Quinidine?
MediHelp rates the interaction as contraindicated. Arsenic trioxide and Quinidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and arsenic trioxide is also linked to torsades de pointes and complete AV block. Combined use raises the risk of life-threatening ventricular arrhythmia.
How serious is the interaction between Arsenic trioxide and Quinidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-QT-prolonging antiarrhythmic. If unavoidable, correct potassium and magnesium and monitor ECG closely.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Artemether / lumefantrine, Chloroquine. The full list is on the Quinidine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
