相互作用
Arsenic trioxide + Dronedarone
重症度: 併用禁忌
Arsenic trioxide and Dronedarone: contraindicated interaction.
最終更新日
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概要
Arsenic trioxide markedly prolongs the QT interval and has caused torsades de pointes. Adding dronedarone, which also prolongs QT, increases that risk.
この相互作用をわかりやすく説明すると
Arsenic trioxide and Dronedarone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Arsenic trioxide belongs to Oncology; Dronedarone belongs to Cardiovascular.
なぜ起こるのか
Additive prolongation of cardiac repolarization.
対処法
Do not combine; select a non-QT-prolonging alternative to dronedarone during arsenic trioxide therapy.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、Arsenic trioxideとDronedaroneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Dronedaroneのその他の相互作用
Arsenic trioxideのその他の相互作用
よくある質問
Can I take Arsenic trioxide with Dronedarone?
MediHelp rates the interaction as contraindicated. Arsenic trioxide and Dronedarone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Arsenic trioxide markedly prolongs the QT interval and has caused torsades de pointes. Adding dronedarone, which also prolongs QT, increases that risk.
How serious is the interaction between Arsenic trioxide and Dronedarone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; select a non-QT-prolonging alternative to dronedarone during arsenic trioxide therapy.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Artemether / lumefantrine. The full list is on the Dronedarone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
