相互作用
Atazanavir + Bosentan
重症度: 重大
Atazanavir and Bosentan: major interaction.
最終更新日 出典: US FDA label
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概要
Atazanavir inhibits CYP3A4 and raises bosentan concentrations substantially, increasing the risk of hepatotoxicity, edema and hypotension. Bosentan may also lower unboosted atazanavir concentrations.
この相互作用をわかりやすく説明すると
Atazanavir and Bosentan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Bosentan belongs to Miscellaneous.
なぜ起こるのか
CYP3A4 inhibition by atazanavir reduces bosentan clearance, while bosentan induction may lower atazanavir levels.
対処法
If coadministered, start bosentan at a reduced dose or frequency in patients already stable on a boosted protease inhibitor, and monitor liver tests and blood pressure. Use ritonavir-boosted atazanavir rather than unboosted atazanavir.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AtazanavirとBosentanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
Bosentanのその他の相互作用
Atazanavirのその他の相互作用
よくある質問
Can I take Atazanavir with Bosentan?
MediHelp rates the interaction as major. Atazanavir and Bosentan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir inhibits CYP3A4 and raises bosentan concentrations substantially, increasing the risk of hepatotoxicity, edema and hypotension. Bosentan may also lower unboosted atazanavir concentrations.
How serious is the interaction between Atazanavir and Bosentan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If coadministered, start bosentan at a reduced dose or frequency in patients already stable on a boosted protease inhibitor, and monitor liver tests and blood pressure. Use ritonavir-boosted atazanavir rather than unboosted atazanavir.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
