相互作用
Atorvastatin + Lasmiditan
重症度: 中等度
Atorvastatin and Lasmiditan: moderate interaction.
最終更新日
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概要
Lasmiditan inhibits P-glycoprotein and BCRP in vitro and could raise atorvastatin exposure. The clinical effect is likely modest, but higher statin levels carry muscle toxicity risk.
この相互作用をわかりやすく説明すると
Atorvastatin and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Lasmiditan belongs to Central Nervous System.
なぜ起こるのか
Inhibition of intestinal P-gp and BCRP efflux increases atorvastatin absorption.
対処法
Counsel patients to report muscle pain or weakness; lasmiditan is used intermittently, so no routine dose change is usually needed.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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アカウントを作成してPro+トライアルを始めると、AtorvastatinとLasmiditanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Atorvastatinのその他の相互作用
Lasmiditanのその他の相互作用
よくある質問
Can I take Atorvastatin with Lasmiditan?
MediHelp rates the interaction as moderate. Atorvastatin and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan inhibits P-glycoprotein and BCRP in vitro and could raise atorvastatin exposure. The clinical effect is likely modest, but higher statin levels carry muscle toxicity risk.
How serious is the interaction between Atorvastatin and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report muscle pain or weakness; lasmiditan is used intermittently, so no routine dose change is usually needed.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
