Drug interactions
Atorvastatin + Lasmiditan
Severity: Moderate
Atorvastatin and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits P-glycoprotein and BCRP in vitro and could raise atorvastatin exposure. The clinical effect is likely modest, but higher statin levels carry muscle toxicity risk.
What this interaction means in plain words
Atorvastatin and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Lasmiditan belongs to Central Nervous System.
Why it happens
Inhibition of intestinal P-gp and BCRP efflux increases atorvastatin absorption.
What to do
Counsel patients to report muscle pain or weakness; lasmiditan is used intermittently, so no routine dose change is usually needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Cyclosporine Major
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Atorvastatin with Lasmiditan?
MediHelp rates the interaction as moderate. Atorvastatin and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan inhibits P-glycoprotein and BCRP in vitro and could raise atorvastatin exposure. The clinical effect is likely modest, but higher statin levels carry muscle toxicity risk.
How serious is the interaction between Atorvastatin and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report muscle pain or weakness; lasmiditan is used intermittently, so no routine dose change is usually needed.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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