相互作用
Azacitidine + Fingolimod
重症度: 重大
Azacitidine and Fingolimod: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Azacitidine causes myelosuppression and fingolimod lowers circulating lymphocytes by sequestering them in lymphoid tissue. Together they may increase the risk of serious infection.
この相互作用をわかりやすく説明すると
Azacitidine and Fingolimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azacitidine belongs to Oncology; Fingolimod belongs to Central Nervous System.
なぜ起こるのか
Additive immunosuppression: lymphocyte sequestration from fingolimod plus bone marrow suppression from azacitidine.
対処法
Avoid the combination where possible, or monitor blood counts and infection signs closely. Consider stopping fingolimod during cytotoxic therapy, remembering its immune effects persist for weeks after discontinuation.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AzacitidineとFingolimodの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Fingolimodのその他の相互作用
Azacitidineのその他の相互作用
よくある質問
Can I take Azacitidine with Fingolimod?
MediHelp rates the interaction as major. Azacitidine and Fingolimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Azacitidine causes myelosuppression and fingolimod lowers circulating lymphocytes by sequestering them in lymphoid tissue. Together they may increase the risk of serious infection.
How serious is the interaction between Azacitidine and Fingolimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or monitor blood counts and infection signs closely. Consider stopping fingolimod during cytotoxic therapy, remembering its immune effects persist for weeks after discontinuation.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
