相互作用
Azathioprine + Ublituximab
重症度: 重大
Azathioprine and Ublituximab: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Ublituximab depletes B cells while azathioprine suppresses lymphocyte proliferation, so combined use may increase the risk of serious infections.
この相互作用をわかりやすく説明すると
Azathioprine and Ublituximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azathioprine belongs to Gastrointestinal Tract; Ublituximab belongs to Miscellaneous.
なぜ起こるのか
Additive immunosuppression from anti-CD20 B-cell depletion and azathioprine lymphocyte suppression.
対処法
Avoid combining where possible, or monitor closely for infection and check blood counts regularly. Consider the duration of effect of each drug when sequencing therapy.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AzathioprineとUblituximabの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Azathioprineのその他の相互作用
Ublituximabのその他の相互作用
よくある質問
Can I take Azathioprine with Ublituximab?
MediHelp rates the interaction as major. Azathioprine and Ublituximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ublituximab depletes B cells while azathioprine suppresses lymphocyte proliferation, so combined use may increase the risk of serious infections.
How serious is the interaction between Azathioprine and Ublituximab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, or monitor closely for infection and check blood counts regularly. Consider the duration of effect of each drug when sequencing therapy.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
