相互作用
Azelastine + Sodium oxybate
重症度: 重大
Azelastine and Sodium oxybate: major interaction.
最終更新日
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概要
Sodium oxybate causes profound CNS and respiratory depression, and other sedating agents add to this effect. Azelastine can cause somnolence and may worsen sedation and impaired alertness when used with sodium oxybate.
この相互作用をわかりやすく説明すると
Azelastine and Sodium oxybate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azelastine belongs to Respiratory; Sodium oxybate belongs to Central Nervous System.
なぜ起こるのか
Additive central nervous system depressant effects.
対処法
Avoid combining where possible and choose a non-sedating alternative such as an intranasal corticosteroid. If used together, monitor for excess sedation and respiratory depression and consider reducing the oxybate dose.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AzelastineとSodium oxybateの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Azelastineのその他の相互作用
Sodium oxybateのその他の相互作用
よくある質問
Can I take Azelastine with Sodium oxybate?
MediHelp rates the interaction as major. Azelastine and Sodium oxybate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sodium oxybate causes profound CNS and respiratory depression, and other sedating agents add to this effect. Azelastine can cause somnolence and may worsen sedation and impaired alertness when used with sodium oxybate.
How serious is the interaction between Azelastine and Sodium oxybate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible and choose a non-sedating alternative such as an intranasal corticosteroid. If used together, monitor for excess sedation and respiratory depression and consider reducing the oxybate dose.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Alfentanil. The full list is on the Azelastine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
