相互作用
Bacitracin-neomycin-polymyxin + Cidofovir
重症度: 重大
Bacitracin-neomycin-polymyxin and Cidofovir: major interaction.
最終更新日
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概要
Systemic polymyxin B, neomycin and bacitracin are nephrotoxic, and cidofovir causes dose-limiting proximal tubular kidney injury. Combined exposure may cause severe renal damage, and cidofovir labeling contraindicates concurrent nephrotoxic agents. Risk applies mainly to systemic or heavily absorbed use rather than small topical applications.
この相互作用をわかりやすく説明すると
Bacitracin-neomycin-polymyxin and Cidofovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bacitracin-neomycin-polymyxin belongs to Anti Bacterial; Cidofovir belongs to Anti Virals.
なぜ起こるのか
Additive nephrotoxicity through direct renal tubular injury by both agents.
対処法
Avoid systemic or heavily absorbed use of these antibiotics during and shortly after cidofovir therapy. If unavoidable, monitor serum creatinine and urine protein closely.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Bacitracin-neomycin-polymyxinとCidofovirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Bacitracin-neomycin-polymyxinのその他の相互作用
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Bacitracin-neomycin-polymyxin 重大
- Atracurium + Bacitracin-neomycin-polymyxin 重大
- Bacitracin-neomycin-polymyxin + Capreomycin 重大
- Bacitracin-neomycin-polymyxin + Cisatracurium 重大
- Bacitracin-neomycin-polymyxin + Pancuronium 重大
- Bacitracin-neomycin-polymyxin + Rocuronium 重大
Cidofovirのその他の相互作用
よくある質問
Can I take Bacitracin-neomycin-polymyxin with Cidofovir?
MediHelp rates the interaction as major. Bacitracin-neomycin-polymyxin and Cidofovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemic polymyxin B, neomycin and bacitracin are nephrotoxic, and cidofovir causes dose-limiting proximal tubular kidney injury. Combined exposure may cause severe renal damage, and cidofovir labeling contraindicates concurrent nephrotoxic agents. Risk applies mainly to systemic or heavily absorbed use rather than small topical applications.
How serious is the interaction between Bacitracin-neomycin-polymyxin and Cidofovir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic or heavily absorbed use of these antibiotics during and shortly after cidofovir therapy. If unavoidable, monitor serum creatinine and urine protein closely.
What other medicines interact with Bacitracin-neomycin-polymyxin?
MediHelp also lists interactions of Bacitracin-neomycin-polymyxin with, for example, Allogeneic cultured keratinocytes / fibroblasts in bovine collagen, Atracurium, Capreomycin. The full list is on the Bacitracin-neomycin-polymyxin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
