相互作用
Baclofen + Oliceridine
重症度: 重大
Baclofen and Oliceridine: major interaction.
最終更新日 出典: UK SmPC
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概要
Opioids combined with other CNS depressants such as baclofen can produce profound sedation, respiratory depression, coma and death. Baclofen may also add to opioid-related urinary retention.
この相互作用をわかりやすく説明すると
Baclofen and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Baclofen belongs to Musculoskeletal; Oliceridine belongs to Musculoskeletal.
なぜ起こるのか
Additive CNS and respiratory depression from opioid agonism and GABA-B agonism.
対処法
Reserve combined use for patients with no adequate alternatives, using the lowest doses and shortest duration. Monitor closely for sedation and respiratory depression.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BaclofenとOliceridineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
Baclofenのその他の相互作用
Oliceridineのその他の相互作用
よくある質問
Can I take Baclofen with Oliceridine?
MediHelp rates the interaction as major. Baclofen and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with other CNS depressants such as baclofen can produce profound sedation, respiratory depression, coma and death. Baclofen may also add to opioid-related urinary retention.
How serious is the interaction between Baclofen and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve combined use for patients with no adequate alternatives, using the lowest doses and shortest duration. Monitor closely for sedation and respiratory depression.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
