相互作用
Amisulpride + Oliceridine
重症度: 重大
Amisulpride and Oliceridine: major interaction.
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Oliceridine is an intravenous opioid, and amisulpride may increase sedation, hypotension and respiratory depression. This is a concern especially with higher doses or in frail patients.
この相互作用をわかりやすく説明すると
Amisulpride and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
なぜ起こるのか
Additive CNS and respiratory depression from mu-opioid agonism and dopamine D2 antagonism.
対処法
Use the lowest effective oliceridine dose and titrate carefully. Monitor sedation level, respiratory rate and oxygen saturation.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmisulprideとOliceridineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
参考文献
Amisulprideのその他の相互作用
Oliceridineのその他の相互作用
よくある質問
Can I take Amisulpride with Oliceridine?
MediHelp rates the interaction as major. Amisulpride and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oliceridine is an intravenous opioid, and amisulpride may increase sedation, hypotension and respiratory depression. This is a concern especially with higher doses or in frail patients.
How serious is the interaction between Amisulpride and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective oliceridine dose and titrate carefully. Monitor sedation level, respiratory rate and oxygen saturation.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
