相互作用
Amobarbital + Oliceridine
重症度: 重大
Amobarbital and Oliceridine: major interaction.
最終更新日 出典: US FDA label
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概要
Combining an opioid with a barbiturate can cause profound sedation, respiratory depression, coma and death. Amobarbital also induces CYP3A4 and may lower oliceridine exposure, reducing analgesia, with risk of toxicity if the inducer is stopped.
この相互作用をわかりやすく説明すると
Amobarbital and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
なぜ起こるのか
Additive CNS and respiratory depression plus CYP3A4 induction that increases oliceridine metabolism.
対処法
Reserve concurrent use for patients without alternatives, using the lowest doses and shortest duration with continuous respiratory and sedation monitoring. Titrate oliceridine to effect and reduce the dose with monitoring if amobarbital is discontinued.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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アカウントを作成してPro+トライアルを始めると、AmobarbitalとOliceridineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
Amobarbitalのその他の相互作用
Oliceridineのその他の相互作用
よくある質問
Can I take Amobarbital with Oliceridine?
MediHelp rates the interaction as major. Amobarbital and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an opioid with a barbiturate can cause profound sedation, respiratory depression, coma and death. Amobarbital also induces CYP3A4 and may lower oliceridine exposure, reducing analgesia, with risk of toxicity if the inducer is stopped.
How serious is the interaction between Amobarbital and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve concurrent use for patients without alternatives, using the lowest doses and shortest duration with continuous respiratory and sedation monitoring. Titrate oliceridine to effect and reduce the dose with monitoring if amobarbital is discontinued.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
