相互作用
Amiodarone + Oliceridine
重症度: 重大
Amiodarone and Oliceridine: major interaction.
最終更新日
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概要
Amiodarone inhibits CYP2D6 and CYP3A4, which metabolize oliceridine, so opioid exposure may rise. This increases the risk of respiratory depression and sedation, and both drugs may affect QT interval.
この相互作用をわかりやすく説明すると
Amiodarone and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Oliceridine belongs to Musculoskeletal.
なぜ起こるのか
Inhibition of CYP2D6 and CYP3A4 metabolism of oliceridine by amiodarone.
対処法
Use lower or less frequent oliceridine doses with close monitoring of respiratory rate and sedation. Check ECG if other QT risks exist, and watch for withdrawal if amiodarone is stopped.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmiodaroneとOliceridineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amiodaroneのその他の相互作用
Oliceridineのその他の相互作用
よくある質問
Can I take Amiodarone with Oliceridine?
MediHelp rates the interaction as major. Amiodarone and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone inhibits CYP2D6 and CYP3A4, which metabolize oliceridine, so opioid exposure may rise. This increases the risk of respiratory depression and sedation, and both drugs may affect QT interval.
How serious is the interaction between Amiodarone and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use lower or less frequent oliceridine doses with close monitoring of respiratory rate and sedation. Check ECG if other QT risks exist, and watch for withdrawal if amiodarone is stopped.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
