相互作用
Baricitinib + Benzathine penicillin g
重症度: 軽度
Baricitinib and Benzathine penicillin g: minor interaction.
最終更新日
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概要
Penicillins can inhibit OAT3, a transporter involved in baricitinib renal elimination, so baricitinib exposure may rise. Labeling advises against strong OAT3 inhibitors such as probenecid, but penicillin G is a much weaker inhibitor and benzathine penicillin gives low sustained levels, so the effect is likely small.
この相互作用をわかりやすく説明すると
Baricitinib and Benzathine penicillin g have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Baricitinib belongs to Musculoskeletal; Benzathine penicillin g belongs to Anti Bacterial.
なぜ起こるのか
Possible weak OAT3 inhibition reducing renal tubular secretion of baricitinib.
対処法
No dose change is generally needed; monitor for baricitinib adverse effects such as infection and cytopenias as usual.
薬剤師に尋ねること
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BaricitinibとBenzathine penicillin gの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Benzathine penicillin gのその他の相互作用
Baricitinibのその他の相互作用
よくある質問
Can I take Baricitinib with Benzathine penicillin g?
MediHelp rates the interaction as minor. Baricitinib and Benzathine penicillin g have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Penicillins can inhibit OAT3, a transporter involved in baricitinib renal elimination, so baricitinib exposure may rise. Labeling advises against strong OAT3 inhibitors such as probenecid, but penicillin G is a much weaker inhibitor and benzathine penicillin gives low sustained levels, so the effect is likely small.
How serious is the interaction between Baricitinib and Benzathine penicillin g?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for baricitinib adverse effects such as infection and cytopenias as usual.
What other medicines interact with Benzathine penicillin g?
MediHelp also lists interactions of Benzathine penicillin g with, for example, Cholera vaccine, Microbiota, Omadacycline. The full list is on the Benzathine penicillin g page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
