相互作用
Betamethasone + Somatropin
重症度: 中等度
Betamethasone and Somatropin: moderate interaction.
最終更新日
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概要
Supraphysiologic glucocorticoid doses can blunt the growth-promoting effect of somatropin, which matters most in children. Growth hormone also reduces cortisol regeneration, so glucocorticoid replacement needs may change.
この相互作用をわかりやすく説明すると
Betamethasone and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Betamethasone belongs to Endocrine; Somatropin belongs to Endocrine.
なぜ起こるのか
Glucocorticoids antagonize growth hormone action, and growth hormone inhibits 11-beta-HSD-1, which alters cortisol activation.
対処法
Use the lowest effective glucocorticoid dose and track growth velocity in children. Reassess glucocorticoid dosing in hypopituitary patients after starting somatropin.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BetamethasoneとSomatropinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Somatropinのその他の相互作用
Betamethasoneのその他の相互作用
よくある質問
Can I take Betamethasone with Somatropin?
MediHelp rates the interaction as moderate. Betamethasone and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Supraphysiologic glucocorticoid doses can blunt the growth-promoting effect of somatropin, which matters most in children. Growth hormone also reduces cortisol regeneration, so glucocorticoid replacement needs may change.
How serious is the interaction between Betamethasone and Somatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective glucocorticoid dose and track growth velocity in children. Reassess glucocorticoid dosing in hypopituitary patients after starting somatropin.
What other medicines interact with Somatropin?
MediHelp also lists interactions of Somatropin with, for example, Acarbose, Albiglutide, Alogliptin-metformin. The full list is on the Somatropin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
