相互作用
Betamethasone + Ciprofloxacin
重症度: 重大
Betamethasone and Ciprofloxacin: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Fluoroquinolones carry a risk of tendinitis and tendon rupture, which is increased by concomitant systemic corticosteroids. The risk is greater in older patients, transplant recipients and those on prolonged therapy.
この相互作用をわかりやすく説明すると
Betamethasone and Ciprofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Betamethasone belongs to Endocrine; Ciprofloxacin belongs to Anti Bacterial.
なぜ起こるのか
Additive tendon toxicity: fluoroquinolones damage tenocytes and collagen while corticosteroids impair tendon healing and matrix synthesis.
対処法
Avoid the combination in older patients where alternatives exist. Instruct patients to stop ciprofloxacin and rest the limb if tendon pain or swelling develops.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BetamethasoneとCiprofloxacinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ciprofloxacinのその他の相互作用
Betamethasoneのその他の相互作用
よくある質問
Can I take Betamethasone with Ciprofloxacin?
MediHelp rates the interaction as major. Betamethasone and Ciprofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluoroquinolones carry a risk of tendinitis and tendon rupture, which is increased by concomitant systemic corticosteroids. The risk is greater in older patients, transplant recipients and those on prolonged therapy.
How serious is the interaction between Betamethasone and Ciprofloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in older patients where alternatives exist. Instruct patients to stop ciprofloxacin and rest the limb if tendon pain or swelling develops.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
