相互作用
Betamethasone + Ofloxacin
重症度: 重大
Betamethasone and Ofloxacin: major interaction.
最終更新日
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概要
Concurrent corticosteroid and fluoroquinolone use increases the risk of tendinitis and tendon rupture, most often of the Achilles tendon. The risk is higher in older patients and with prolonged or high-dose steroid exposure.
この相互作用をわかりやすく説明すると
Betamethasone and Ofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Betamethasone belongs to Endocrine; Ofloxacin belongs to Anti Bacterial.
なぜ起こるのか
Both drug classes impair tendon collagen turnover and tenocyte function, producing additive tendon toxicity.
対処法
Avoid the combination where possible, especially in patients over 60 or with renal impairment. If used, advise the patient to stop the quinolone and rest at the first sign of tendon pain or swelling.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BetamethasoneとOfloxacinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ofloxacinのその他の相互作用
Betamethasoneのその他の相互作用
よくある質問
Can I take Betamethasone with Ofloxacin?
MediHelp rates the interaction as major. Betamethasone and Ofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent corticosteroid and fluoroquinolone use increases the risk of tendinitis and tendon rupture, most often of the Achilles tendon. The risk is higher in older patients and with prolonged or high-dose steroid exposure.
How serious is the interaction between Betamethasone and Ofloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, especially in patients over 60 or with renal impairment. If used, advise the patient to stop the quinolone and rest at the first sign of tendon pain or swelling.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
