相互作用
Brexpiprazole + Pheniramine
重症度: 中等度
Brexpiprazole and Pheniramine: moderate interaction.
最終更新日
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概要
Pheniramine is a sedating first-generation antihistamine, and brexpiprazole is also sedating. Together they may cause pronounced drowsiness and impaired psychomotor performance, and anticholinergic effects may be additive.
この相互作用をわかりやすく説明すると
Brexpiprazole and Pheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Pheniramine belongs to Respiratory.
なぜ起こるのか
Additive CNS depression through histamine H1 receptor antagonism and other receptor blockade.
対処法
Counsel patients about drowsiness and avoiding driving or hazardous tasks. Prefer a non-sedating antihistamine if one is suitable.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BrexpiprazoleとPheniramineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Brexpiprazoleのその他の相互作用
Pheniramineのその他の相互作用
よくある質問
Can I take Brexpiprazole with Pheniramine?
MediHelp rates the interaction as moderate. Brexpiprazole and Pheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pheniramine is a sedating first-generation antihistamine, and brexpiprazole is also sedating. Together they may cause pronounced drowsiness and impaired psychomotor performance, and anticholinergic effects may be additive.
How serious is the interaction between Brexpiprazole and Pheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and avoiding driving or hazardous tasks. Prefer a non-sedating antihistamine if one is suitable.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
