相互作用
Calcifediol + Captopril-hydrochlorothiazide
重症度: 中等度
Calcifediol and Captopril-hydrochlorothiazide: moderate interaction.
最終更新日
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概要
Thiazide diuretics reduce urinary calcium excretion, and calcifediol increases calcium absorption from the gut. Together they can produce hypercalcemia, which may cause nausea, confusion, arrhythmias and kidney problems.
この相互作用をわかりやすく説明すると
Calcifediol and Captopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcifediol belongs to Musculoskeletal; Captopril-hydrochlorothiazide belongs to Cardiovascular.
なぜ起こるのか
Hydrochlorothiazide enhances renal calcium reabsorption while calcifediol (a vitamin D metabolite) increases intestinal calcium absorption, producing additive rises in serum calcium.
対処法
Measure serum calcium at baseline and periodically during combined therapy, especially in patients with renal impairment. Reduce the calcifediol dose or stop the thiazide if hypercalcemia develops.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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アカウントを作成してPro+トライアルを始めると、CalcifediolとCaptopril-hydrochlorothiazideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Captopril-hydrochlorothiazideのその他の相互作用
Calcifediolのその他の相互作用
よくある質問
Can I take Calcifediol with Captopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Calcifediol and Captopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics reduce urinary calcium excretion, and calcifediol increases calcium absorption from the gut. Together they can produce hypercalcemia, which may cause nausea, confusion, arrhythmias and kidney problems.
How serious is the interaction between Calcifediol and Captopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure serum calcium at baseline and periodically during combined therapy, especially in patients with renal impairment. Reduce the calcifediol dose or stop the thiazide if hypercalcemia develops.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
