相互作用
Canagliflozin-metformin + Entecavir
重症度: 中等度
Canagliflozin-metformin and Entecavir: moderate interaction.
最終更新日
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概要
Entecavir labeling warns of lactic acidosis with nucleoside analogues, and metformin independently carries this risk. Combined use may add to the risk, particularly with renal impairment or liver disease.
この相互作用をわかりやすく説明すると
Canagliflozin-metformin and Entecavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Entecavir belongs to Anti Virals.
なぜ起こるのか
Both drugs can impair lactate metabolism, via mitochondrial toxicity for entecavir and inhibited gluconeogenesis for metformin, giving additive risk.
対処法
Monitor renal function and watch for symptoms of lactic acidosis such as malaise, abdominal pain and hyperventilation. Stop therapy and check lactate if these develop.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Canagliflozin-metforminとEntecavirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Canagliflozin-metforminのその他の相互作用
Entecavirのその他の相互作用
よくある質問
Can I take Canagliflozin-metformin with Entecavir?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Entecavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entecavir labeling warns of lactic acidosis with nucleoside analogues, and metformin independently carries this risk. Combined use may add to the risk, particularly with renal impairment or liver disease.
How serious is the interaction between Canagliflozin-metformin and Entecavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and watch for symptoms of lactic acidosis such as malaise, abdominal pain and hyperventilation. Stop therapy and check lactate if these develop.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
