相互作用
Dapagliflozin-metformin + Entecavir
重症度: 中等度
Dapagliflozin-metformin and Entecavir: moderate interaction.
最終更新日
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概要
Entecavir and metformin have both been linked to lactic acidosis, and entecavir labeling notes this risk, particularly in patients with hepatic or renal impairment. Using them together may add to that risk.
この相互作用をわかりやすく説明すると
Dapagliflozin-metformin and Entecavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Entecavir belongs to Anti Virals.
なぜ起こるのか
Additive risk of lactic acidosis, possibly via mitochondrial toxicity with entecavir and impaired lactate clearance with metformin.
対処法
Monitor for symptoms of lactic acidosis and check renal and hepatic function regularly. Stop metformin if lactic acidosis is suspected.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Dapagliflozin-metforminとEntecavirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Dapagliflozin-metforminのその他の相互作用
Entecavirのその他の相互作用
よくある質問
Can I take Dapagliflozin-metformin with Entecavir?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Entecavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entecavir and metformin have both been linked to lactic acidosis, and entecavir labeling notes this risk, particularly in patients with hepatic or renal impairment. Using them together may add to that risk.
How serious is the interaction between Dapagliflozin-metformin and Entecavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for symptoms of lactic acidosis and check renal and hepatic function regularly. Stop metformin if lactic acidosis is suspected.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
