相互作用
Isavuconazonium + Ketoconazole
重症度: 併用禁忌
Isavuconazonium and Ketoconazole: contraindicated interaction.
最終更新日
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概要
Ketoconazole raises isavuconazole concentrations, increasing the risk of adverse effects including hepatotoxicity and QT shortening. Labeling contraindicates strong CYP3A4 inhibitors with isavuconazonium.
この相互作用をわかりやすく説明すると
Isavuconazonium and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isavuconazonium belongs to Anti Fungals; Ketoconazole belongs to Anti Fungals.
なぜ起こるのか
Ketoconazole inhibits CYP3A4, the main enzyme clearing isavuconazole.
対処法
Do not combine; two azole antifungals are not appropriate together. Select a single agent based on the infection being treated.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、IsavuconazoniumとKetoconazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ketoconazoleのその他の相互作用
Isavuconazoniumのその他の相互作用
よくある質問
Can I take Isavuconazonium with Ketoconazole?
MediHelp rates the interaction as contraindicated. Isavuconazonium and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketoconazole raises isavuconazole concentrations, increasing the risk of adverse effects including hepatotoxicity and QT shortening. Labeling contraindicates strong CYP3A4 inhibitors with isavuconazonium.
How serious is the interaction between Isavuconazonium and Ketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; two azole antifungals are not appropriate together. Select a single agent based on the infection being treated.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
