相互作用
Carbenoxolone + Torsemide
重症度: 重大
Carbenoxolone and Torsemide: major interaction.
最終更新日
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概要
Carbenoxolone has mineralocorticoid-like activity causing sodium and water retention and potassium loss. With torsemide, hypokalemia can be pronounced and the diuretic effect may be opposed.
この相互作用をわかりやすく説明すると
Carbenoxolone and Torsemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Carbenoxolone inhibits 11-beta-hydroxysteroid dehydrogenase, giving mineralocorticoid excess that adds to loop diuretic potassium wasting.
対処法
Avoid the combination where possible. If used together, monitor serum potassium and blood pressure closely and replace potassium as required.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CarbenoxoloneとTorsemideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Torsemideのその他の相互作用
よくある質問
Can I take Carbenoxolone with Torsemide?
MediHelp rates the interaction as major. Carbenoxolone and Torsemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbenoxolone has mineralocorticoid-like activity causing sodium and water retention and potassium loss. With torsemide, hypokalemia can be pronounced and the diuretic effect may be opposed.
How serious is the interaction between Carbenoxolone and Torsemide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used together, monitor serum potassium and blood pressure closely and replace potassium as required.
What other medicines interact with Torsemide?
MediHelp also lists interactions of Torsemide with, for example, Amikacin, Amiodarone, Chlorthalidone. The full list is on the Torsemide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
