相互作用
Digoxin + Torsemide
重症度: 重大
Digoxin and Torsemide: major interaction.
最終更新日 出典: US FDA label
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概要
Loop diuretics can cause hypokalemia and hypomagnesemia, which sensitise the myocardium to digoxin and increase the risk of toxicity and ventricular arrhythmias. The interaction is well documented and clinically important, especially in older patients and those with renal impairment. Digoxin concentrations themselves are not usually changed.
この相互作用をわかりやすく説明すると
Digoxin and Torsemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Digoxin belongs to Cardiovascular; Torsemide belongs to Cardiovascular.
なぜ起こるのか
Pharmacodynamic: diuretic-induced potassium and magnesium depletion increases digoxin binding to Na+/K+-ATPase and enhances its arrhythmogenic effects.
対処法
Monitor serum potassium and magnesium regularly, keeping potassium in the normal to high-normal range. Supplement electrolytes or add a potassium-sparing agent if needed.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DigoxinとTorsemideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
Torsemideのその他の相互作用
Digoxinのその他の相互作用
よくある質問
Can I take Digoxin with Torsemide?
MediHelp rates the interaction as major. Digoxin and Torsemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Loop diuretics can cause hypokalemia and hypomagnesemia, which sensitise the myocardium to digoxin and increase the risk of toxicity and ventricular arrhythmias. The interaction is well documented and clinically important, especially in older patients and those with renal impairment. Digoxin concentrations themselves are not usually changed.
How serious is the interaction between Digoxin and Torsemide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium regularly, keeping potassium in the normal to high-normal range. Supplement electrolytes or add a potassium-sparing agent if needed.
What other medicines interact with Torsemide?
MediHelp also lists interactions of Torsemide with, for example, Amikacin, Amiodarone, Carbenoxolone. The full list is on the Torsemide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
