相互作用
Dexamethasone-tobramycin + Torsemide
重症度: 重大
Dexamethasone-tobramycin and Torsemide: major interaction.
最終更新日 出典: US FDA label
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概要
Loop diuretics combined with systemic aminoglycosides increase the risk of ototoxicity and nephrotoxicity, especially with volume depletion. This is relevant mainly with systemic tobramycin.
この相互作用をわかりやすく説明すると
Dexamethasone-tobramycin and Torsemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexamethasone-tobramycin belongs to Anti Bacterial; Torsemide belongs to Cardiovascular.
なぜ起こるのか
Additive ototoxic and nephrotoxic effects, with diuretic-induced volume depletion raising aminoglycoside exposure in the kidney and inner ear.
対処法
Monitor renal function, tobramycin levels and hearing, keep the patient well hydrated, and avoid the combination if alternatives exist.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Dexamethasone-tobramycinとTorsemideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
Dexamethasone-tobramycinのその他の相互作用
Torsemideのその他の相互作用
よくある質問
Can I take Dexamethasone-tobramycin with Torsemide?
MediHelp rates the interaction as major. Dexamethasone-tobramycin and Torsemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Loop diuretics combined with systemic aminoglycosides increase the risk of ototoxicity and nephrotoxicity, especially with volume depletion. This is relevant mainly with systemic tobramycin.
How serious is the interaction between Dexamethasone-tobramycin and Torsemide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, tobramycin levels and hearing, keep the patient well hydrated, and avoid the combination if alternatives exist.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
