相互作用
Amiodarone + Torsemide
重症度: 重大
Amiodarone and Torsemide: major interaction.
最終更新日 出典: US FDA label
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概要
Torsemide can cause hypokalemia and hypomagnesemia, which increase the risk of QT prolongation and torsades de pointes in patients taking amiodarone. Amiodarone prolongs repolarization, so electrolyte loss lowers the threshold for arrhythmia. The risk is highest with high diuretic doses, renal dysfunction, bradycardia, structural heart disease, female sex and other QT-prolonging drugs.
この相互作用をわかりやすく説明すると
Amiodarone and Torsemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Torsemide belongs to Cardiovascular.
なぜ起こるのか
Additive pharmacodynamic effect: loop diuretic-induced potassium and magnesium depletion potentiates the QT-prolonging effect of amiodarone.
対処法
Check serum potassium and magnesium before starting and periodically during co-therapy, especially after dose changes or intercurrent illness with vomiting or diarrhea. Replete deficits promptly and keep potassium in the high-normal range (about 4.0 mmol/L or above) and magnesium in the normal range.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmiodaroneとTorsemideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
Amiodaroneのその他の相互作用
Torsemideのその他の相互作用
よくある質問
Can I take Amiodarone with Torsemide?
MediHelp rates the interaction as major. Amiodarone and Torsemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Torsemide can cause hypokalemia and hypomagnesemia, which increase the risk of QT prolongation and torsades de pointes in patients taking amiodarone. Amiodarone prolongs repolarization, so electrolyte loss lowers the threshold for arrhythmia. The risk is highest with high diuretic doses, renal dysfunction, bradycardia, structural heart disease, female sex and other QT-prolonging drugs.
How serious is the interaction between Amiodarone and Torsemide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium before starting and periodically during co-therapy, especially after dose changes or intercurrent illness with vomiting or diarrhea. Replete deficits promptly and keep potassium in the high-normal range (about 4.0 mmol/L or above) and magnesium in the normal range.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
