相互作用
Carbidopa-entacapone-levodopa + Sapropterin
重症度: 中等度
Carbidopa-entacapone-levodopa and Sapropterin: moderate interaction.
最終更新日
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概要
Sapropterin is a cofactor for tyrosine hydroxylase and nitric oxide synthase, and combined use with levodopa has been associated with reports of convulsions, overstimulation and irritability. Labeling advises caution, though evidence is limited.
この相互作用をわかりやすく説明すると
Carbidopa-entacapone-levodopa and Sapropterin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Sapropterin belongs to Miscellaneous.
なぜ起こるのか
Not firmly established; possibly enhanced dopaminergic and nitric oxide pathway activity.
対処法
Monitor for agitation, irritability and seizures after starting sapropterin and reduce doses if these occur.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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アカウントを作成してPro+トライアルを始めると、Carbidopa-entacapone-levodopaとSapropterinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Carbidopa-entacapone-levodopaのその他の相互作用
- Carbidopa-entacapone-levodopa + Isocarboxazid 併用禁忌
- Carbidopa-entacapone-levodopa + Phenelzine 併用禁忌
- Carbidopa-entacapone-levodopa + Selegiline transdermal 併用禁忌
- Carbidopa-entacapone-levodopa + Tranylcypromine 併用禁忌
- Amisulpride + Carbidopa-entacapone-levodopa 重大
- Asenapine transdermal + Carbidopa-entacapone-levodopa 重大
Sapropterinのその他の相互作用
よくある質問
Can I take Carbidopa-entacapone-levodopa with Sapropterin?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Sapropterin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sapropterin is a cofactor for tyrosine hydroxylase and nitric oxide synthase, and combined use with levodopa has been associated with reports of convulsions, overstimulation and irritability. Labeling advises caution, though evidence is limited.
How serious is the interaction between Carbidopa-entacapone-levodopa and Sapropterin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, irritability and seizures after starting sapropterin and reduce doses if these occur.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
