相互作用
Levodopa + Sapropterin
重症度: 中等度
Levodopa and Sapropterin: moderate interaction.
最終更新日
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概要
Concomitant use has been associated with neurologic events such as seizures, exacerbated seizures, over-stimulation and irritability. The cause is not clearly established.
この相互作用をわかりやすく説明すると
Levodopa and Sapropterin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levodopa belongs to Central Nervous System; Sapropterin belongs to Miscellaneous.
なぜ起こるのか
Mechanism not established; possible effects on catecholamine neurotransmitter synthesis since sapropterin is a cofactor for tyrosine hydroxylase.
対処法
Monitor neurologic status, including seizures and agitation, during combined use. Adjust the dose of either drug if events occur.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、LevodopaとSapropterinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Sapropterinのその他の相互作用
Levodopaのその他の相互作用
よくある質問
Can I take Levodopa with Sapropterin?
MediHelp rates the interaction as moderate. Levodopa and Sapropterin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concomitant use has been associated with neurologic events such as seizures, exacerbated seizures, over-stimulation and irritability. The cause is not clearly established.
How serious is the interaction between Levodopa and Sapropterin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neurologic status, including seizures and agitation, during combined use. Adjust the dose of either drug if events occur.
What other medicines interact with Sapropterin?
MediHelp also lists interactions of Sapropterin with, for example, Avanafil, Carbidopa-entacapone-levodopa, Carbidopa-levodopa. The full list is on the Sapropterin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
