相互作用
Cefalexin + Plazomicin
重症度: 中等度
Cefalexin and Plazomicin: moderate interaction.
最終更新日
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概要
Plazomicin is an aminoglycoside with labeled risks of nephrotoxicity and ototoxicity. Other agents that can impair renal function, including cephalosporins in some reports, may add to kidney injury and raise plazomicin exposure.
この相互作用をわかりやすく説明すると
Cefalexin and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefalexin belongs to Anti Bacterial; Plazomicin belongs to Anti Bacterial.
なぜ起こるのか
Additive nephrotoxic potential, with reduced renal clearance increasing aminoglycoside accumulation and ototoxicity.
対処法
Monitor serum creatinine and plazomicin concentrations, and adjust dosing to renal function per labeling. Watch for hearing loss, tinnitus or vestibular symptoms.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CefalexinとPlazomicinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cefalexinのその他の相互作用
Plazomicinのその他の相互作用
よくある質問
Can I take Cefalexin with Plazomicin?
MediHelp rates the interaction as moderate. Cefalexin and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Plazomicin is an aminoglycoside with labeled risks of nephrotoxicity and ototoxicity. Other agents that can impair renal function, including cephalosporins in some reports, may add to kidney injury and raise plazomicin exposure.
How serious is the interaction between Cefalexin and Plazomicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and plazomicin concentrations, and adjust dosing to renal function per labeling. Watch for hearing loss, tinnitus or vestibular symptoms.
What other medicines interact with Cefalexin?
MediHelp also lists interactions of Cefalexin with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefalexin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
