相互作用
Cefotetan + Enoxaparin
重症度: 中等度
Cefotetan and Enoxaparin: moderate interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Cefotetan contains an N-methylthiotetrazole group that can reduce vitamin K-dependent clotting factors and impair platelet function. This can add to the bleeding risk of enoxaparin, especially in debilitated patients.
この相互作用をわかりやすく説明すると
Cefotetan and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefotetan belongs to Anti Bacterial; Enoxaparin belongs to Cardiovascular.
なぜ起こるのか
Additive hemostatic impairment via vitamin K antagonism and platelet dysfunction caused by the cephalosporin side chain.
対処法
Monitor for bleeding and check PT/INR during prolonged courses. Give vitamin K if coagulopathy develops or select an alternative antibiotic.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CefotetanとEnoxaparinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Enoxaparinのその他の相互作用
Cefotetanのその他の相互作用
よくある質問
Can I take Cefotetan with Enoxaparin?
MediHelp rates the interaction as moderate. Cefotetan and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefotetan contains an N-methylthiotetrazole group that can reduce vitamin K-dependent clotting factors and impair platelet function. This can add to the bleeding risk of enoxaparin, especially in debilitated patients.
How serious is the interaction between Cefotetan and Enoxaparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and check PT/INR during prolonged courses. Give vitamin K if coagulopathy develops or select an alternative antibiotic.
What other medicines interact with Enoxaparin?
MediHelp also lists interactions of Enoxaparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Enoxaparin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
