相互作用
Cefotetan + Warfarin
重症度: 重大
Cefotetan and Warfarin: major interaction.
最終更新日
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概要
Cefotetan has been associated with hypoprothrombinemia and bleeding, which can add to the effect of warfarin and markedly raise the INR.
この相互作用をわかりやすく説明すると
Cefotetan and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cefotetan belongs to Anti Bacterial; Warfarin belongs to Cardiovascular.
なぜ起こるのか
Its N-methylthiotetrazole side chain inhibits vitamin K epoxide reductase and gut flora reduce vitamin K availability, adding to warfarin effect.
対処法
Monitor INR closely during therapy and consider vitamin K supplementation or an alternative antibiotic if INR rises. Reduce warfarin dose as indicated.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CefotetanとWarfarinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Warfarinのその他の相互作用
Cefotetanのその他の相互作用
よくある質問
Can I take Cefotetan with Warfarin?
MediHelp rates the interaction as major. Cefotetan and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cefotetan has been associated with hypoprothrombinemia and bleeding, which can add to the effect of warfarin and markedly raise the INR.
How serious is the interaction between Cefotetan and Warfarin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR closely during therapy and consider vitamin K supplementation or an alternative antibiotic if INR rises. Reduce warfarin dose as indicated.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
