相互作用
Cefotetan + Heparin
重症度: 中等度
Cefotetan and Heparin: moderate interaction.
最終更新日
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概要
Cefotetan contains an N-methylthiotetrazole side chain that can cause hypoprothrombinemia and bleeding, particularly in malnourished or elderly patients. With heparin the bleeding tendency may be increased.
この相互作用をわかりやすく説明すると
Cefotetan and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefotetan belongs to Anti Bacterial; Heparin belongs to Cardiovascular.
なぜ起こるのか
Additive hemostatic impairment: cefotetan inhibits vitamin K epoxide reductase-dependent clotting factor synthesis while heparin potentiates antithrombin.
対処法
Monitor coagulation parameters and watch for bleeding signs during co-therapy. Give vitamin K if the prothrombin time is prolonged, or select an alternative antibiotic.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CefotetanとHeparinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Heparinのその他の相互作用
Cefotetanのその他の相互作用
よくある質問
Can I take Cefotetan with Heparin?
MediHelp rates the interaction as moderate. Cefotetan and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefotetan contains an N-methylthiotetrazole side chain that can cause hypoprothrombinemia and bleeding, particularly in malnourished or elderly patients. With heparin the bleeding tendency may be increased.
How serious is the interaction between Cefotetan and Heparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor coagulation parameters and watch for bleeding signs during co-therapy. Give vitamin K if the prothrombin time is prolonged, or select an alternative antibiotic.
What other medicines interact with Heparin?
MediHelp also lists interactions of Heparin with, for example, Defibrotide, Ketorolac, Oritavancin. The full list is on the Heparin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
