相互作用
Ceftriaxone + Lactated Ringer's solution
重症度: 重大
Ceftriaxone and Lactated Ringer's solution: major interaction.
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Ceftriaxone can form insoluble calcium-ceftriaxone precipitates when mixed with calcium-containing solutions such as lactated Ringer's. Fatal cases of lung and kidney deposits have occurred in neonates. Labeling contraindicates concomitant use in neonates and prohibits mixing in the same line for all patients.
この相互作用をわかりやすく説明すると
Ceftriaxone and Lactated Ringer's solution can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Physicochemical incompatibility: ceftriaxone binds calcium to form insoluble calcium salts that precipitate in lines or in vivo.
対処法
Do not reconstitute or dilute ceftriaxone with lactated Ringer's or any calcium-containing solution, and do not give through the same line simultaneously. In patients older than 28 days, sequential administration is acceptable only if the line is thoroughly flushed with a compatible fluid between infusions.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CeftriaxoneとLactated Ringer's solutionの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
参考文献
- Ceftriaxone for Injection Prescribing Information - Contraindications and Warnings — FDA Label
- Rocephin Summary of Product Characteristics — EMA SmPC
Ceftriaxoneのその他の相互作用
よくある質問
Can I take Ceftriaxone with Lactated Ringer's solution?
MediHelp rates the interaction as major. Ceftriaxone and Lactated Ringer's solution can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ceftriaxone can form insoluble calcium-ceftriaxone precipitates when mixed with calcium-containing solutions such as lactated Ringer's. Fatal cases of lung and kidney deposits have occurred in neonates. Labeling contraindicates concomitant use in neonates and prohibits mixing in the same line for all patients.
How serious is the interaction between Ceftriaxone and Lactated Ringer's solution?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not reconstitute or dilute ceftriaxone with lactated Ringer's or any calcium-containing solution, and do not give through the same line simultaneously. In patients older than 28 days, sequential administration is acceptable only if the line is thoroughly flushed with a compatible fluid between infusions.
What other medicines interact with Ceftriaxone?
MediHelp also lists interactions of Ceftriaxone with, for example, Calcium chloride, Calcium gluconate, Calcium. The full list is on the Ceftriaxone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
