相互作用
Ceftriaxone + Ringer's solution
重症度: 併用禁忌
Ceftriaxone and Ringer's solution: contraindicated interaction.
最終更新日 出典: US FDA label
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概要
Ceftriaxone can form an insoluble ceftriaxone-calcium precipitate when mixed with calcium-containing solutions such as Ringer's or lactated Ringer's. Fatal cases of crystalline deposits in the lungs and kidneys have occurred in neonates given ceftriaxone and calcium-containing intravenous fluids. In neonates the combination is contraindicated, and in older patients it must not be mixed or co-infused in the same line.
この相互作用をわかりやすく説明すると
Ceftriaxone and Ringer's solution are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Ceftriaxone binds calcium to form poorly soluble ceftriaxone-calcium salt, which precipitates in IV lines and in vivo.
対処法
Do not give ceftriaxone to neonates (up to 28 days) who need or are expected to need calcium-containing IV solutions, including Ringer's.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、CeftriaxoneとRinger's solutionの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
- Rocephin (ceftriaxone) Prescribing Information - Contraindications and Warnings: Interaction with calcium-containing products — FDA Label
- Ceftriaxone Summary of Product Characteristics - Contraindications and Interactions with calcium — EMA SmPC
Ceftriaxoneのその他の相互作用
よくある質問
Can I take Ceftriaxone with Ringer's solution?
MediHelp rates the interaction as contraindicated. Ceftriaxone and Ringer's solution are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ceftriaxone can form an insoluble ceftriaxone-calcium precipitate when mixed with calcium-containing solutions such as Ringer's or lactated Ringer's. Fatal cases of crystalline deposits in the lungs and kidneys have occurred in neonates given ceftriaxone and calcium-containing intravenous fluids. In neonates the combination is contraindicated, and in older patients it must not be mixed or co-infused in the same line.
How serious is the interaction between Ceftriaxone and Ringer's solution?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give ceftriaxone to neonates (up to 28 days) who need or are expected to need calcium-containing IV solutions, including Ringer's.
What other medicines interact with Ceftriaxone?
MediHelp also lists interactions of Ceftriaxone with, for example, Calcium chloride, Calcium gluconate, Calcium. The full list is on the Ceftriaxone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
