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相互作用

Certolizumab pegol + Measles mumps and rubella vaccine

重症度: 併用禁忌

Certolizumab pegol and Measles mumps and rubella vaccine: contraindicated interaction.

最終更新日

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このページの臨床コンテンツは英語でのみ提供されています。

概要

The live attenuated vaccine relies on a competent immune system to limit viral replication, and certolizumab pegol (a TNF-alpha antagonist) weakens that control. Disseminated vaccine-strain infection is possible and the antibody response to the vaccine may also be reduced.

この相互作用をわかりやすく説明すると

Certolizumab pegol and Measles mumps and rubella vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Certolizumab pegol belongs to Musculoskeletal; Measles mumps and rubella vaccine belongs to Miscellaneous.

エビデンスレベル: High

なぜ起こるのか

Certolizumab pegol-mediated immunosuppression allows replication of a live attenuated virus

対処法

Do not give live vaccines during treatment; where possible, vaccinate at least 4 weeks before starting the immunosuppressant, and delay after stopping until immune function has recovered.

薬剤師に尋ねること

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+会員向け

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アカウントを作成してPro+トライアルを始めると、Certolizumab pegolとMeasles mumps and rubella vaccineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

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よくある質問

Can I take Certolizumab pegol with Measles mumps and rubella vaccine?

MediHelp rates the interaction as contraindicated. Certolizumab pegol and Measles mumps and rubella vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The live attenuated vaccine relies on a competent immune system to limit viral replication, and certolizumab pegol (a TNF-alpha antagonist) weakens that control. Disseminated vaccine-strain infection is possible and the antibody response to the vaccine may also be reduced.

How serious is the interaction between Certolizumab pegol and Measles mumps and rubella vaccine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live vaccines during treatment; where possible, vaccinate at least 4 weeks before starting the immunosuppressant, and delay after stopping until immune function has recovered.

What other medicines interact with Measles mumps and rubella vaccine?

MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.

完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで

MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。

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