相互作用
Cilostazol + Vonoprazan
重症度: 中等度
Cilostazol and Vonoprazan: moderate interaction.
最終更新日
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概要
Vonoprazan may increase cilostazol exposure through effects on CYP2C19 and CYP3A4, which could increase cilostazol adverse effects such as headache and tachycardia.
この相互作用をわかりやすく説明すると
Cilostazol and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Vonoprazan belongs to Gastrointestinal Tract.
なぜ起こるのか
Vonoprazan may inhibit CYP2C19 and CYP3A4 metabolism of cilostazol.
対処法
Consider reducing cilostazol to 50 mg twice daily during co-administration. Monitor heart rate and tolerability.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CilostazolとVonoprazanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cilostazolのその他の相互作用
Vonoprazanのその他の相互作用
よくある質問
Can I take Cilostazol with Vonoprazan?
MediHelp rates the interaction as moderate. Cilostazol and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vonoprazan may increase cilostazol exposure through effects on CYP2C19 and CYP3A4, which could increase cilostazol adverse effects such as headache and tachycardia.
How serious is the interaction between Cilostazol and Vonoprazan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing cilostazol to 50 mg twice daily during co-administration. Monitor heart rate and tolerability.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
