相互作用
Cisplatin + Topotecan
重症度: 重大
Cisplatin and Topotecan: major interaction.
最終更新日
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概要
Cisplatin and topotecan both suppress bone marrow, and together they produce more severe neutropenia and thrombocytopenia than either drug alone. Myelosuppression can be dose-limiting and may lead to infection or bleeding.
この相互作用をわかりやすく説明すると
Cisplatin and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cisplatin belongs to Oncology; Topotecan belongs to Oncology.
なぜ起こるのか
Additive pharmacodynamic myelosuppression, with possible sequence-dependent enhancement of toxicity.
対処法
Monitor complete blood counts frequently and reduce topotecan dose or delay cycles for severe cytopenias. Follow established regimen sequencing and use growth factor support when indicated.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CisplatinとTopotecanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Cisplatinのその他の相互作用
Topotecanのその他の相互作用
よくある質問
Can I take Cisplatin with Topotecan?
MediHelp rates the interaction as major. Cisplatin and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cisplatin and topotecan both suppress bone marrow, and together they produce more severe neutropenia and thrombocytopenia than either drug alone. Myelosuppression can be dose-limiting and may lead to infection or bleeding.
How serious is the interaction between Cisplatin and Topotecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and reduce topotecan dose or delay cycles for severe cytopenias. Follow established regimen sequencing and use growth factor support when indicated.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
