相互作用
Cyclosporine + Topotecan
重症度: 重大
Cyclosporine and Topotecan: major interaction.
最終更新日
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概要
Cyclosporine inhibits both P-gp and BCRP, and co-administration has been shown to increase topotecan exposure, particularly oral topotecan. This may increase the risk of severe myelosuppression.
この相互作用をわかりやすく説明すると
Cyclosporine and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Cyclosporine inhibits P-gp and BCRP efflux transport of topotecan.
対処法
Avoid combination with oral topotecan. If IV topotecan is required, monitor blood counts frequently and reduce the dose as needed.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CyclosporineとTopotecanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Topotecanのその他の相互作用
よくある質問
Can I take Cyclosporine with Topotecan?
MediHelp rates the interaction as major. Cyclosporine and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine inhibits both P-gp and BCRP, and co-administration has been shown to increase topotecan exposure, particularly oral topotecan. This may increase the risk of severe myelosuppression.
How serious is the interaction between Cyclosporine and Topotecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination with oral topotecan. If IV topotecan is required, monitor blood counts frequently and reduce the dose as needed.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
