相互作用
Darunavir + Topotecan
重症度: 重大
Darunavir and Topotecan: major interaction.
最終更新日
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概要
Darunavir, usually boosted with ritonavir or cobicistat, inhibits P-gp and may increase topotecan exposure. This may worsen myelosuppression.
この相互作用をわかりやすく説明すると
Darunavir and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Darunavir belongs to Anti Virals; Topotecan belongs to Oncology.
なぜ起こるのか
Darunavir and its booster inhibit P-gp (and potentially BCRP) efflux of topotecan.
対処法
Avoid with oral topotecan. With IV topotecan, monitor blood counts and consider dose reduction.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DarunavirとTopotecanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Topotecanのその他の相互作用
Darunavirのその他の相互作用
よくある質問
Can I take Darunavir with Topotecan?
MediHelp rates the interaction as major. Darunavir and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Darunavir, usually boosted with ritonavir or cobicistat, inhibits P-gp and may increase topotecan exposure. This may worsen myelosuppression.
How serious is the interaction between Darunavir and Topotecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid with oral topotecan. With IV topotecan, monitor blood counts and consider dose reduction.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
