相互作用
Clomipramine + Dopamine
重症度: 重大
Clomipramine and Dopamine: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Clomipramine can potentiate pressor and arrhythmogenic effects of sympathomimetics by blocking catecholamine reuptake. Dopamine responses may be exaggerated or unpredictable.
この相互作用をわかりやすく説明すると
Clomipramine and Dopamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clomipramine belongs to Central Nervous System; Dopamine belongs to Cardiovascular.
なぜ起こるのか
Inhibition of norepinephrine reuptake by clomipramine alters response to dopamine.
対処法
Use low initial dopamine doses with continuous blood pressure and ECG monitoring.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ClomipramineとDopamineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Dopamineのその他の相互作用
Clomipramineのその他の相互作用
よくある質問
Can I take Clomipramine with Dopamine?
MediHelp rates the interaction as major. Clomipramine and Dopamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clomipramine can potentiate pressor and arrhythmogenic effects of sympathomimetics by blocking catecholamine reuptake. Dopamine responses may be exaggerated or unpredictable.
How serious is the interaction between Clomipramine and Dopamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use low initial dopamine doses with continuous blood pressure and ECG monitoring.
What other medicines interact with Dopamine?
MediHelp also lists interactions of Dopamine with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Selegiline transdermal. The full list is on the Dopamine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
