相互作用
Clomipramine + Glycopyrrolate
重症度: 中等度
Clomipramine and Glycopyrrolate: moderate interaction.
最終更新日
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概要
Both drugs have anticholinergic activity, so combined use may worsen dry mouth, constipation, urinary retention, blurred vision and tachycardia. Anticholinergic burden is especially important in older patients.
この相互作用をわかりやすく説明すると
Clomipramine and Glycopyrrolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Glycopyrrolate belongs to Respiratory.
なぜ起こるのか
Additive antimuscarinic effects at peripheral and central cholinergic receptors.
対処法
Monitor for anticholinergic effects such as urinary retention, ileus and heat intolerance. Reduce the dose of one drug or choose an alternative if effects are troublesome.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ClomipramineとGlycopyrrolateの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clomipramineのその他の相互作用
Glycopyrrolateのその他の相互作用
よくある質問
Can I take Clomipramine with Glycopyrrolate?
MediHelp rates the interaction as moderate. Clomipramine and Glycopyrrolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic activity, so combined use may worsen dry mouth, constipation, urinary retention, blurred vision and tachycardia. Anticholinergic burden is especially important in older patients.
How serious is the interaction between Clomipramine and Glycopyrrolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as urinary retention, ileus and heat intolerance. Reduce the dose of one drug or choose an alternative if effects are troublesome.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
