医薬品リファレンス
Glycopyrrolate
Glycopyrrolate is a medicine in the class respiratory.
- 薬効分類: Respiratory
最終更新日 出典: US FDA label
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このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Respiratory
- 一般的な剤形
- 錠剤, 溶液
- 一般的な規格
- 1 mg/5 ml, 1.5 mg
- 既知の相互作用
- 80 (重大: 1 · 中等度: 48 · 軽度: 31)
- 商品名
- 2
- 国・市場
- 1
作用のしくみ
Competitive inhibitor of acetylcholine receptors on certain peripheral tissues, including salivary glands; indirectly reduces the rate of salivation by preventing stimulation of these receptors.
妊娠と授乳
- 妊娠
- Unknown Injection: very little crosses the placenta; widely used in anaesthesia, including caesarean section, without fetal heart effects. Oral and inhaled forms: no human data; no birth defects in rats or rabbits. Some UK injection labels: not recommended. Use only if clearly needed.
- 授乳
- Safe No milk data; it is poorly absorbed by the infant (quaternary drug). Single doses (e.g. anaesthesia) and inhaled or skin use are unlikely to matter. Long-term oral use may reduce milk supply; watch the infant's weight gain.
報告されている副作用
- Dry mouth
- Vomiting
- Constipation
- Flushing
- Nasal congestion
- Urinary retention
禁忌
- Medical conditions that preclude anticholinergic therapy (e.g., glaucoma, paralytic ileus, unstable cardiovascular status in acute hemorrhage, severe ulcerative colitis, toxic megacolon, myasthenia gravis).
- Concomitant solid oral dosage forms of potassium chloride.
注意が必要な方
- Constipation or intestinal pseudo-obstruction: assess for constipation, particularly within 4-5 days of initial dosing or after a dose increase.
- Diarrhea may signal incomplete mechanical intestinal obstruction; if suspected, discontinue and evaluate.
- Heat prostration can occur in high ambient temperature; avoid hot environments.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (80)
- Glycopyrrolate + Potassium chloride Major
- Amitriptyline + Glycopyrrolate Moderate
- Atropine + Glycopyrrolate Moderate
- Bethanechol + Glycopyrrolate Moderate
- Chlorpromazine + Glycopyrrolate Moderate
- Clomipramine + Glycopyrrolate Moderate
- Clozapine + Glycopyrrolate Moderate
- Cyclizine + Glycopyrrolate Moderate
- Cyclobenzaprine + Glycopyrrolate Moderate
- Darifenacin + Glycopyrrolate Moderate
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Glycopyrrolateの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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同じ分類のほかの薬剤
よくある質問
What is Glycopyrrolate used for?
Glycopyrrolate is a medicine in the class respiratory.
What side effects have been reported with Glycopyrrolate?
Dry mouth, Vomiting, Constipation, Flushing, Nasal congestion, Urinary retention.
Can Glycopyrrolate be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Injection: very little crosses the placenta; widely used in anaesthesia, including caesarean section, without fetal heart effects. Oral and inhaled forms: no human data; no birth defects in rats or rabbits. Some UK injection labels: not recommended. Use only if clearly needed. Breastfeeding: Safe. No milk data; it is poorly absorbed by the infant (quaternary drug). Single doses (e.g. anaesthesia) and inhaled or skin use are unlikely to matter. Long-term oral use may reduce milk supply; watch the infant's weight gain.
What does Glycopyrrolate interact with?
MediHelp lists 80 known interactions for Glycopyrrolate. Major: 1 · Moderate: 48 · Minor: 31. The most serious include Potassium chloride, Amitriptyline, Atropine.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
