相互作用
Clomipramine + Liothyronine
重症度: 中等度
Clomipramine and Liothyronine: moderate interaction.
最終更新日
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概要
Thyroid hormones can increase sensitivity to catecholamines and tricyclics may enhance this effect. The combination can raise the risk of tachyarrhythmias and CNS stimulation, particularly with excess thyroid hormone. Tricyclic effect may also be accelerated when thyroid hormone is used for augmentation.
この相互作用をわかりやすく説明すると
Clomipramine and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Liothyronine belongs to Endocrine.
なぜ起こるのか
Thyroid hormone increases adrenergic receptor sensitivity, adding to tricyclic noradrenergic and cardiac effects.
対処法
Monitor heart rate, rhythm and thyroid function, and watch for agitation or tremor. Keep thyroid replacement dose at the lowest effective level.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ClomipramineとLiothyronineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clomipramineのその他の相互作用
Liothyronineのその他の相互作用
よくある質問
Can I take Clomipramine with Liothyronine?
MediHelp rates the interaction as moderate. Clomipramine and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormones can increase sensitivity to catecholamines and tricyclics may enhance this effect. The combination can raise the risk of tachyarrhythmias and CNS stimulation, particularly with excess thyroid hormone. Tricyclic effect may also be accelerated when thyroid hormone is used for augmentation.
How serious is the interaction between Clomipramine and Liothyronine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and thyroid function, and watch for agitation or tremor. Keep thyroid replacement dose at the lowest effective level.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
