相互作用
Clonidine + Guanfacine
重症度: 重大
Clonidine and Guanfacine: major interaction.
最終更新日
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概要
Both are central alpha-2 adrenergic agonists, so combining them duplicates therapy and increases the risk of hypotension, bradycardia and sedation. Patients with conduction disease may be at greater risk of heart block.
この相互作用をわかりやすく説明すると
Clonidine and Guanfacine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clonidine belongs to Cardiovascular; Guanfacine belongs to Cardiovascular.
なぜ起こるのか
Additive central alpha-2 agonism reduces sympathetic outflow, causing pharmacodynamic synergism.
対処法
Avoid using both together unless there is a clear indication; if used, monitor heart rate, blood pressure and sedation closely. Taper one agent gradually when stopping to avoid rebound hypertension.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ClonidineとGuanfacineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clonidineのその他の相互作用
Guanfacineのその他の相互作用
よくある質問
Can I take Clonidine with Guanfacine?
MediHelp rates the interaction as major. Clonidine and Guanfacine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are central alpha-2 adrenergic agonists, so combining them duplicates therapy and increases the risk of hypotension, bradycardia and sedation. Patients with conduction disease may be at greater risk of heart block.
How serious is the interaction between Clonidine and Guanfacine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using both together unless there is a clear indication; if used, monitor heart rate, blood pressure and sedation closely. Taper one agent gradually when stopping to avoid rebound hypertension.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
